Zollinger-Ellison Syndrome — Presentation, Diagnosis, Therapy
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چکیده
Zollinger-Ellison syndrome results from a pancreatic tumor in the non-beta islet cells, which stimulates the maximal activity of the gastric acid-secreting cells, resulting in gastrointestinal ulceration of the mucosa. Multiple endocrine neoplasia type 1 (MEN 1) is a familial autosomal dominant syndrome that includes Zollinger-Ellison syndrome as part of it; however, Zollinger-Ellison syndrome may still occur sporadically.
منابع مشابه
An Unusual Presentation of Zollinger-Ellison Syndrome
Zollinger-Ellison syndrome is an often progressive, persistent and frequently life-threatening disease, described for the first time as characterized by ulceration of the upper jejunum, hypersecretion of gastric acid and non-beta islet cell tumors of the pancreas; this syndrome is due to the hypersecretion of gastrin. We report a case of Zollinger-Ellison syndrome presenting as severe esophagit...
متن کاملGastric acid secretion and diagnosis of Zollinger-Ellison syndrome.
One hundred and fifty patients suspected of having Zollinger-Ellison syndrome were investigated. High plasma gastrin levels were found in 23 and in 16 a diagnosis of Zollinger-Ellison syndrome was confirmed. Measurement of the basal and maximal acid outputs showed that these simpler investigations have considerable value as screening tests for the selection of those patients in whom gastrin stu...
متن کاملThe Zollinger-Ellison syndrome in a child.
The Zollinger-Ellison syndrome was encountered in a boy aged 11 years who presented with a bulbar duodenal ulcer causing intractable pain and bleeding. The diagnosis was made by finding an overnight fasting gastric secretion of 1,300 ml containing 134 m-equiv/HCl, and little change of secretion after maximal histamine stimulus. A circumscribed non-beta islet cell pancreatic tumour was excised, ...
متن کاملSignificance of gastric analysis with particular reference to the diagnosis of Zollinger-Ellison syndrome.
Various criteria in gastric analysis currently used for the diagnosis of the Zollinger-Ellison syndrome were assessed in cases of endoscopically normal gastric mucosa, gastric ulcer and duodenal ulcer. New criteria consisting of BSV greater than 350 ml/hr, BAO greater than 25 mEq/hr, MAO greater than 60 mEq/hr, and BAO/MAO greater than 0.7 were proposed to differentiate the Zollinger-Ellison sy...
متن کاملIs total gastrectomy still a viable option in the management of patients with the Zollinger-Ellison syndrome?
The Zollinger-Ellison syndrome, which is due to the secretion of gastrin from non-beta islet cell tumors of the pancreas, results in gastric hypersecretion and severe peptic ulcer disease. In the 1970s H2 blockers became the mainstay of therapy. More recent evidence indicates that early surgical intervention aimed at tumor extirpation results in improved outcome. The purpose of this paper is to...
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